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KMID : 0043319980210050610
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.610 ~ p.614
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Immunomodulating Activity of DW-116, A New Quinolone Antibiotic
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Moon Eun-Yi
Choi Chung-Ha
Pyo Suhk-Neung
Chung Yong-Ho
Yoon Sung-June
Lee Dug-Keun
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Abstract
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DW-116, [1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquino-line-3-carboxylic acid hydrochloride}, is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(-) bacteria. DW-116 was evaluated for the immunomodulating activities, which is one of the efforts to investigate the mechanism of action related to the good in vivo antibacterial efficacy. The results of in vitro studies revealed there was no statistically significant increase in B and T lymphocyte proliferation. But the results of in vivo studies showed that the number of plaque forming cells (PFC), the amount of polyclonal antibodies and delayed-type hypersensitivity (DTH) were significantly increased after the repeat administration with 12 and 60 mg/kg of DW-116. Taken together, these results proposed that immunostimulting effect of DW-116 could be one of the action mechanisms for demonstrating in vivo antibacterial activities under these experimental conditions.
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KEYWORD
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DW-116, PFC, DTH, Immunoglpobin
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